Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characterize latent components of genetic associations, we apply truncated singular value decompositi...

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Vydáno v:Nat Commun
Hlavní autoři: Tanigawa, Yosuke, Li, Jiehan, Justesen, Johanne M., Horn, Heiko, Aguirre, Matthew, DeBoever, Christopher, Chang, Chris, Narasimhan, Balasubramanian, Lage, Kasper, Hastie, Trevor, Park, Chong Y., Bejerano, Gill, Ingelsson, Erik, Rivas, Manuel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731283/
https://ncbi.nlm.nih.gov/pubmed/31492854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11953-9
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