l-Type Amino Acid Transporter 1 (LAT1/Lat1)-Utilizing Prodrugs Can Improve the Delivery of Drugs into Neurons, Astrocytes and Microglia

l-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral l-amino acids as well as several drugs and prodrugs across the blood-brain barrier (BBB). However, the BBB is not the only barrier that hinders drugs acting effectively within the brain; the brain parenchymal cell...

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Publicat a:Sci Rep
Autors principals: Huttunen, Johanna, Peltokangas, Soile, Gynther, Mikko, Natunen, Teemu, Hiltunen, Mikko, Auriola, Seppo, Ruponen, Marika, Vellonen, Kati-Sisko, Huttunen, Kristiina M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731241/
https://ncbi.nlm.nih.gov/pubmed/31492955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-49009-z
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