Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Human neural stem cell cultures provide progenitor cells that are potential cells of origin for brain cancers. However, the extent to which genetic predisposition to tumor formation can be faithfully captured in stem cell lines is uncertain. Here, we evaluated neuroepithelial stem (NES) cells, repre...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Stem Cell
Hlavní autoři: Huang, Miller, Tailor, Jignesh, Zhen, Qiqi, Gillmor, Aaron H., Miller, Matthew L., Weishaupt, Holger, Chen, Justin, Zheng, Tina, Nash, Emily K., McHenry, Lauren K., An, Zhenyi, Ye, Fubaiyang, Takashima, Yasuhiro, Clarke, James, Ayetey, Harold, Cavalli, Florence M.G., Luu, Betty, Moriarity, Branden S., Ilkhanizadeh, Shirin, Chavez, Lukas, Yu, Chunying, Kurian, Kathreena M., Magnaldo, Thierry, Sevenet, Nicolas, Koch, Philipp, Pollard, Steven M., Dirks, Peter, Snyder, Michael P., Largaespada, David A., Cho, Yoon Jae, Phillips, Joanna J., Swartling, Fredrik J., Morrissy, A. Sorana, Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Smith, Austin, Weiss, William A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731167/
https://ncbi.nlm.nih.gov/pubmed/31204176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.05.013
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky