Nuclear TARBP2 drives oncogenic dysregulation of RNA splicing and decay

Post-transcriptional regulation of RNA stability is a key step in gene expression control. We describe a regulatory program, mediated by the RNA binding protein TARBP2, that controls RNA stability in the nucleus. TARBP2 binding to pre-mRNAs results in increased intron retention, subsequently leading...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Fish, Lisa, Navickas, Albertas, Culbertson, Bruce, Xu, Yichen, Nguyen, Hoang C.B., Zhang, Steven, Hochman, Myles, Okimoto, Ross, Dill, Brian D., Molina, Henrik, Najafabadi, Hamed S., Alarcón, Claudio, Ruggero, Davide, Goodarzi, Hani
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731133/
https://ncbi.nlm.nih.gov/pubmed/31300274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.06.001
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