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Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer’s disease
The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism. We show that in all primary human tissues tested, and partic...
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| Publié dans: | Nat Commun |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5714957/ https://ncbi.nlm.nih.gov/pubmed/29030541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00867-z |
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