Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome

Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical in Leigh Syndrome (LS), a common MD presentation, leading to motor and respiratory deficits, seizures and premature death. However,...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Bolea, Irene, Gella, Alejandro, Sanz, Elisenda, Prada-Dacasa, Patricia, Menardy, Fabien, Bard, Angela M, Machuca-Márquez, Pablo, Eraso-Pichot, Abel, Mòdol-Caballero, Guillem, Navarro, Xavier, Kalume, Franck, Quintana, Albert
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2019
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6731060/
https://ncbi.nlm.nih.gov/pubmed/31403401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47163
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