Muscle Xenografts Reproduce Key Molecular Features of Facioscapulohumeral Muscular Dystrophy

Aberrant expression of DUX4, a gene unique to humans and primates, causes Facioscapulohumeral Muscular Dystrophy-1 (FSHD), yet the pathogenic mechanism is unknown. As transgenic overexpression models have largely failed to replicate the genetic changes seen in FSHD, many studies of endogenously expr...

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Pubblicato in:Exp Neurol
Autori principali: Mueller, Amber L., O’Neill, Andrea, Jones, Takako I., Llach, Anna, Rojas, Luis Alejandro, Sakellariou, Paraskevi, Stadler, Guido, Wright, Woodring E., Eyerman, David, Jones, Peter L., Bloch, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730665/
https://ncbi.nlm.nih.gov/pubmed/31306642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113011
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