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mTOR senses intracellular pH through lysosome dispersion from RHEB
Acidity, generated in hypoxia or hypermetabolic states, perturbs homeostasis and is a feature of solid tumors. That acid peripherally disperses lysosomes is a three-decade-old observation, yet one little understood or appreciated. However, recent work has recognized the inhibitory impact this spatia...
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| Publicado en: | Bioessays |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6730656/ https://ncbi.nlm.nih.gov/pubmed/31157925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201800265 |
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