Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor

Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death. These pathological features are also caused by the human immunodeficiency virus-1 (HIV) envelope protein gp120, which incre...

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Publicado en:Front Cell Neurosci
Autores principales: Speidell, Andrew, Asuni, Gino Paolo, Avdoshina, Valeria, Scognamiglio, Serena, Forcelli, Patrick, Mocchetti, Italo
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730486/
https://ncbi.nlm.nih.gov/pubmed/31543761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00398
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