Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death

The profound neuroprotection observed in poly(ADP-ribose) polymerase-1 (PARP-1) null mice to ischemic and excitotoxic injury positions PARP-1 as a major mediator of neuronal cell death. We report here that apoptosis-inducing factor (AIF) mediates PARP-1-dependent glutamate excitotoxicity in a caspas...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wang, Hongmin, Yu, Seong-Woon, Koh, David W., Lew, Jasmine, Coombs, Carmen, Bowers, William, Federoff, Howard J., Poirier, Guy G., Dawson, Ted M., Dawson, Valina L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730219/
https://ncbi.nlm.nih.gov/pubmed/15574746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3461-04.2004
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