Mapping Netrin Receptor Binding Reveals Domains of Unc5 Regulating Its Tyrosine Phosphorylation

Netrin and its receptors Unc5 and deleted in colorectal carcinoma (DCC) regulate axon guidance and cell migration. We defined domains involved in the interactions between netrin-1, DCC, and Unc5c. We show that Unc5 requires both Ig domains to interact with netrin. DCC binds through the fourth fibron...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Kruger, Robert P., Lee, Jeeyong, Li, Weiquan, Guan, Kun-Liang
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2004
Subjects:
Cellular/Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6730211/
https://ncbi.nlm.nih.gov/pubmed/15574733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3715-04.2004
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