Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain

A local increase in amyloid-β peptide (Aβ) is closely associated with synaptic dysfunction in the brain in Alzheimer's disease. Here, we report on the catabolic mechanism of Aβ at the presynaptic sites. Neprilysin, an Aβ-degrading enzyme, expressed by recombinant adeno-associated viral vector-m...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Iwata, Nobuhisa, Mizukami, Hiroaki, Shirotani, Keiro, Takaki, Yoshie, Muramatsu, Shin-ichi, Lu, Bao, Gerard, Norma P., Gerard, Craig, Ozawa, Keiya, Saido, Takaomi C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729819/
https://ncbi.nlm.nih.gov/pubmed/14749444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4792-03.2004
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