Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Accumulation of amyloid-β peptide (Aβ) in the brain is closely associated with cognitive decline in Alzheimer's disease (AD). Stereotaxic infusion of neprilysin-encoding viral vectors into the hippocampus has been shown to decrease Aβ in AD-model mice, but more efficient and global delivery is...

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Detalhes bibliográficos
Main Authors: Iwata, Nobuhisa, Sekiguchi, Misaki, Hattori, Yoshino, Takahashi, Akane, Asai, Masashi, Ji, Bin, Higuchi, Makoto, Staufenbiel, Matthias, Muramatsu, Shin-ichi, Saido, Takaomi C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600598/
https://ncbi.nlm.nih.gov/pubmed/23503602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01472
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