Viral-Induced Spinal Motor Neuron Death Is Non-Cell-Autonomous and Involves Glutamate Excitotoxicity

Neuroadapted Sindbis virus (NSV) is a neurotropic virus capable of inducing the death of spinal motor neurons in mice and rats. In this study we investigated the mechanisms that underlie NSV-induced motor neuron death. We found that many degenerating spinal motor neurons were not infected directly w...

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Pubblicato in:J Neurosci
Autori principali: Darman, Jessica, Backovic, Stephanie, Dike, Sonny, Maragakis, Nicholas J., Krishnan, Chitra, Rothstein, Jeffrey D., Irani, David N., Kerr, Douglas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729638/
https://ncbi.nlm.nih.gov/pubmed/15329404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2002-04.2004
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