Block of AMPA Receptor Desensitization by a Point Mutation outside the Ligand-Binding Domain

Desensitization of ionotropic glutamate receptors (GluRs), specifically the AMPA receptor subtype, shapes the postsynaptic response at certain synapses in the brain. All known mechanisms that alter desensitization, either pharmacological or mutational, are associated with the ligand-binding domain....

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Veröffentlicht in:J Neurosci
Hauptverfasser: Yelshansky, Maria V., Sobolevsky, Alexander I., Jatzke, Claudia, Wollmuth, Lonnie P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2004
Schlagworte:
Cellular/Molecular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729461/
https://ncbi.nlm.nih.gov/pubmed/15152033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0757-04.2004
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