A Drosophila Temperature-Sensitive Seizure Mutant in Phosphoglycerate Kinase Disrupts ATP Generation and Alters Synaptic Function

A novel paralytic mutant, nubian, was identified in a behavioral screen for conditional temperature-sensitive seizure mutants in Drosophila melanogaster. nubian mutants display reduced lifespan, abnormal motor behavior, altered synaptic structure, and defective neurotransmitter release. The nubian m...

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Publicat a:J Neurosci
Autors principals: Wang, Ping, Saraswati, Sudipta, Guan, Zhuo, Watkins, Carol J., Wurtman, Richard J., Littleton, J. Troy
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2004
Matèries:
Cellular/Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729406/
https://ncbi.nlm.nih.gov/pubmed/15140922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0542-04.2004
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