Abnormal Ca(2+)-Calmodulin-Dependent Protein Kinase II Function Mediates Synaptic and Motor Deficits in Experimental Parkinsonism

The NMDA receptor complex represents a key molecular element in the pathogenesis of long-term synaptic changes and motor abnormalities in Parkinson's disease (PD). Here we show that NMDA receptor 1 (NR1) subunit and postsynaptic density (PSD)-95 protein levels are selectively reduced in the PSD...

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Pubblicato in:J Neurosci
Autori principali: Picconi, Barbara, Gardoni, Fabrizio, Centonze, Diego, Mauceri, Daniela, Cenci, M. Angela, Bernardi, Giorgio, Calabresi, Paolo, Di Luca, Monica
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2004
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729313/
https://ncbi.nlm.nih.gov/pubmed/15190099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1224-04.2004
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