MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway

BACKGROUND: Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological rol...

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Pubblicato in:J Exp Clin Cancer Res
Autori principali: Yang, Qing, Lang, Chuandong, Wu, Zhengquan, Dai, Yuhu, He, Shaofu, Guo, Wei, Huang, Shuai, Du, Hong, Ren, Dong, Peng, Xinsheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729064/
https://ncbi.nlm.nih.gov/pubmed/31488180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1374-x
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