Spironolactone ameliorates endothelial dysfunction through inhibition of the AGE/RAGE axis in a chronic renal failure rat model

BACKGROUND: Spironolactone can improve endothelial dysfunction in the setting of heart failure and diabetes models. However, its beneficial effect in the cardiovascular system is not clear in the setting of non-diabetic renal failure. We conducted this study to investigate whether spironolactone can...

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Bibliographic Details
Published in:BMC Nephrol
Main Authors: Wang, Chun-Cheng, Lee, An-Sheng, Liu, Shu-Hui, Chang, Kuan-Cheng, Shen, Ming-Yi, Chang, Chiz-Tzung
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729054/
https://ncbi.nlm.nih.gov/pubmed/31492107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12882-019-1534-4
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