Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

BACKGROUND: m6A modification has been proved to play an important role in many biological processes. METTL3 as the main methyltransferase for methylation process has been found to be upregulated in many cancers, including CRC. Here, we investigate m6A modification and the underlying mechanism of MET...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Peng, Wen, Li, Jie, Chen, Ranran, Gu, Qiou, Yang, Peng, Qian, Wenwei, Ji, Dongjian, Wang, Qingyuan, Zhang, Zhiyuan, Tang, Junwei, Sun, Yueming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729001/
https://ncbi.nlm.nih.gov/pubmed/31492150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1408-4
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