Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues

Spatial mapping of proteins in tissues is hindered by limitations in multiplexing, sensitivity, and throughput. Here we report immunostaining with signal amplification by exchange reaction (Immuno-SABER), which achieves highly multiplexed signal amplification via DNA-barcoded antibodies and orthogon...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Saka, Sinem K., Wang, Yu, Kishi, Jocelyn Y., Zhu, Allen, Zeng, Yitian, Xie, Wenxin, Kirli, Koray, Yapp, Clarence, Cicconet, Marcelo, Beliveau, Brian J., Lapan, Sylvain W., Yin, Siyuan, Lin, Millicent, Boyden, Edward S., Kaeser, Pascal S., Pihan, German, Church, George M., Yin, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728175/
https://ncbi.nlm.nih.gov/pubmed/31427819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0207-y
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