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Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing signaling networks but is challenging due to thei...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Nguyen, Huy Quoc, Roy, Jagoree, Harink, Björn, Damle, Nikhil P, Latorraca, Naomi R, Baxter, Brian C, Brower, Kara, Longwell, Scott A, Kortemme, Tanja, Thorn, Kurt S, Cyert, Martha S, Fordyce, Polly Morrell
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728138/
https://ncbi.nlm.nih.gov/pubmed/31282865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40499
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