Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

Transient, regulated binding of globular protein domains to Short Linear Motifs (SLiMs) in disordered regions of other proteins drives cellular signaling. Mapping the energy landscapes of these interactions is essential for deciphering and perturbing signaling networks but is challenging due to thei...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nguyen, Huy Quoc, Roy, Jagoree, Harink, Björn, Damle, Nikhil P, Latorraca, Naomi R, Baxter, Brian C, Brower, Kara, Longwell, Scott A, Kortemme, Tanja, Thorn, Kurt S, Cyert, Martha S, Fordyce, Polly Morrell
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728138/
https://ncbi.nlm.nih.gov/pubmed/31282865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40499
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