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Developmental Thyroid Hormone Insufficiency Induces a Cortical Brain Malformation and Learning Impairments: A Cross-Fostering Study

Thyroid hormones (THs) are essential for brain development, but few rodent models exist that link TH inefficiency to apical neurodevelopmental endpoints. We have previously described a structural anomaly, a heterotopia, in the brains of rats treated in utero with propylthiouracil (PTU). However, how...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: O’Shaughnessy, Katherine L., Kosian, Patricia A., Ford, Jermaine L., Oshiro, Wendy M., Degitz, Sigmund J., Gilbert, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727983/
https://ncbi.nlm.nih.gov/pubmed/29385626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy016
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