Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist as PET Imaging Probe ([(18)F]N2B-0518) for GluN2B Subunit in the Brain

GluN2B is the most studied subunit of N-methyl-D-aspartate receptors (NMDARs) and implicated in the pathologies of various central nervous system disorders and neurodegenerative diseases. As pan NMDAR antagonists often produce debilitating side effects, new approaches in drug discovery have shifted...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Fu, Hualong, Tang, Weiting, Chen, Zhen, Belov, Vasily V., Zhang, Genwei, Shao, Tuo, Zhang, Xiaofei, Yu, Qingzhen, Rong, Jian, Deng, Xiaoyun, Han, Wei, Myers, Scott J., Giffenig, Pilar, Wang, Lu, Josephson, Lee, Shao, Yihan, Davenport, April T., Daunais, James B., Papisov, Mikhail, Yuan, Hongjie, Li, Zijing, Traynelis, Stephen F., Liang, Steven H.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727982/
https://ncbi.nlm.nih.gov/pubmed/30698943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00591
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料