Synthesis and Preliminary Evaluations of a Triazole-cored Antagonist as PET Imaging Probe ([(18)F]N2B-0518) for GluN2B Subunit in the Brain

GluN2B is the most studied subunit of N-methyl-D-aspartate receptors (NMDARs) and implicated in the pathologies of various central nervous system disorders and neurodegenerative diseases. As pan NMDAR antagonists often produce debilitating side effects, new approaches in drug discovery have shifted...

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Published in:ACS Chem Neurosci
Main Authors: Fu, Hualong, Tang, Weiting, Chen, Zhen, Belov, Vasily V., Zhang, Genwei, Shao, Tuo, Zhang, Xiaofei, Yu, Qingzhen, Rong, Jian, Deng, Xiaoyun, Han, Wei, Myers, Scott J., Giffenig, Pilar, Wang, Lu, Josephson, Lee, Shao, Yihan, Davenport, April T., Daunais, James B., Papisov, Mikhail, Yuan, Hongjie, Li, Zijing, Traynelis, Stephen F., Liang, Steven H.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727982/
https://ncbi.nlm.nih.gov/pubmed/30698943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00591
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