Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization

Enterovirus D68 (EV-D68) undergoes structural transformation between mature, cell-entry intermediate (A-particle) and empty forms throughout its life cycle. Structural information for the various forms and antibody-bound capsids will facilitate the development of effective vaccines and therapeutics...

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Vydáno v:Nat Microbiol
Hlavní autoři: Zheng, Qingbing, Zhu, Rui, Xu, Longfa, He, Maozhou, Yan, Xiaodong, Liu, Dongxiao, Yin, Zhichao, Wu, Yangtao, Li, Yongchao, Yang, Lisheng, Hou, Wangheng, Li, Shuxuan, Li, Zizhen, Chen, Zhenqin, Li, Zhihai, Yu, Hai, Gu, Ying, Zhang, Jun, Baker, Timothy S., Zhou, Z. Hong, Graham, Barney S., Cheng, Tong, Li, Shaowei, Xia, Ningshao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727974/
https://ncbi.nlm.nih.gov/pubmed/30397341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0275-7
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