A Unique SUMO-Interacting Motif of Trx2 Is Critical for Its Mitochondrial Presequence Processing and Anti-oxidant Activity

OBJECTIVE: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H(2)O(2) in mitochondria. It has been widely reported that Trx2 deletion in cells or mice generates massive r...

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Udgivet i:Front Physiol
Main Authors: Chen, Chaofei, Wang, Kang, Zhang, Haifeng, Zhou, Huanjiao Jenny, Chen, Yuxin, Min, Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727865/
https://ncbi.nlm.nih.gov/pubmed/31555141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.01089
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