Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

Chronic stress is a key risk factor for depression, and microglia have been implicated in the pathogenesis of the disease. Recent studies show that the Nod-like receptor protein 3 (NLRP3) inflammasome is expressed in microglia and may play a crucial role in depression. However, the mechanism of NLRP...

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Publicado en:Front Mol Neurosci
Autores principales: Feng, Xiujing, Zhao, Yuan, Yang, Tianyuan, Song, Manyu, Wang, Chaoran, Yao, Yujie, Fan, Honggang
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727781/
https://ncbi.nlm.nih.gov/pubmed/31555091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00210
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