A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury

BACKGROUND: GATA3 is a dual-zinc finger transcription factor that regulates gene expression in many developing tissues. In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to develop kidneys. In humans, autosomal dominant GATA3 mutations can cause renal aplasia as...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Grigorieva, Irina V., Oszwald, Andre, Grigorieva, Elena F., Schachner, Helga, Neudert, Barbara, Ostendorf, Tammo, Floege, Jürgen, Lindenmeyer, Maja T., Cohen, Clemens D., Panzer, Ulf, Aigner, Christof, Schmidt, Alice, Grosveld, Frank, Thakker, Rajesh V., Rees, Andrew Jackson, Kain, Renate
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727249/
https://ncbi.nlm.nih.gov/pubmed/31405951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018111143
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