Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells.

Glioblastoma remains difficult to treat with chemotherapy and patients with tumors expressing high levels of (O(6)-methylguanine DNA methyltransferase (MGMT) usually respond poorly to standard temozolomide therapy. We have previously shown that the selective AURKA inhibitor alisertib potently inhibi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Sak, Müge, Zumbar, Cory T., King, Paul D., Li, Xiaohui, Mifsud, Caroline S., Usubalieva, Aisulu, Anderson, Charles D., Chesnick, Hailey M., McElroy, Joseph P., Chakravarti, Arnab, Burton, Eric C., Lehman, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727196/
https://ncbi.nlm.nih.gov/pubmed/31011934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03164-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados