A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

Caspase‐4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non‐canonical inflammasome, which drives inflammatory responses during Gram‐negative bacterial infections. It remains unclear whether other proteins regulate cytosolic LPS sensing, particularly in human cel...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Benaoudia, Sacha, Martin, Amandine, Puig Gamez, Marta, Gay, Gabrielle, Lagrange, Brice, Cornut, Maxence, Krasnykov, Kyrylo, Claude, Jean‐Baptiste, Bourgeois, Cyril F, Hughes, Sandrine, Gillet, Benjamin, Allatif, Omran, Corbin, Antoine, Ricci, Romeo, Henry, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727027/
https://ncbi.nlm.nih.gov/pubmed/31353801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201948235
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