LKB1 deficiency promotes proliferation and invasion of glioblastoma through activation of mTOR and focal adhesion kinase signaling pathways

Liver kinase B1 (LKB1), a serine/threonine kinase, is frequently inactivated in several types of human cancers. To date, inactivation of LKB1 tumor suppressor has rarely been reported in glioblastoma. In this study, we investigated LKB1 status, biological significance, and therapeutic implications i...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Zhang, Keqiang, Wang, Jinghan, Wang, Jinhui, Luh, Frank, Liu, Xiyong, Yang, Lu, Liu, Yun-Ru, Su, Leila, Yang, Yu-Chen SH, Chu, Peiguo, Yen, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726989/
https://ncbi.nlm.nih.gov/pubmed/31497348
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