Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis

In hepatocarcinogenesis induced by diethylnitrosamine (DEN) in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a pivotal role. The livers of transgenic mice with a hepatocyte‐specific human BRAFV600E mutation weighed 4.5 times more than that of normal mice a...

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Detalles Bibliográficos
Publicado en:Cancer Sci
Main Authors: Tanaka, Hiroki, Horioka, Kie, Yamamoto, Masahiro, Asari, Masaru, Okuda, Katsuhiro, Yamazaki, Kosuke, Shimizu, Keiko, Ogawa, Katsuhiro
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726687/
https://ncbi.nlm.nih.gov/pubmed/31301081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14130
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