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Ground State Destabilization in Uracil DNA Glycosylase: Let Us Not Forget “Tautomeric Strain” in Substrates
Enzymes like uracil DNA glycosylase (UDG) can achieve ground state destabilization, by polarizing substrates to mimic rare tautomers. On the basis of computed nucleus independent chemical shifts, NICS(1)(zz), and harmonic oscillator model of electron delocalization (HOMED) analyses, of quantum mecha...
Shranjeno v:
| izdano v: | J Am Chem Soc |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6726543/ https://ncbi.nlm.nih.gov/pubmed/31434485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b06447 |
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