Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas

PURPOSE: Both gain-of-function EZH2 mutations and inactivating histone acetyltransferases mutations, such as CREBBP and EP300, have been implicated in the pathogenesis of germinal center (GC) derived lymphomas. We hypothesized that direct inhibition of EZH2 and HDAC would be synergistic in GC-derive...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Lue, Jennifer K., Prabhu, Sathyen A., Liu, Yuxuan, Gonzalez, Yulissa, Verma, Akanksha, Mundi, Prabhjot S., Abshiru, Nebiyu, Camarillo, Jeannie M., Mehta, Swasti, Chen, Emily I., Qiao, Changhong, Nandakumar, Renu, Cremers, Serge, Kelleher, Neil L., Elemento, Olivier, Amengual, Jennifer E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726529/
https://ncbi.nlm.nih.gov/pubmed/30979734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3989
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