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Glutaminase activity of L-asparaginase contributes to durable preclinical activity against acute lymphoblastic leukemia
We and others have reported that the anticancer activity of L-asparaginase (ASNase) against asparagine synthetase (ASNS)-positive cell types requires ASNase glutaminase activity, whereas anticancer activity against ASNS-negative cell types does not. Here we attempted to disentangle the relationship...
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| Wydane w: | Mol Cancer Ther |
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| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6726508/ https://ncbi.nlm.nih.gov/pubmed/31209181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-1329 |
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