Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

Aggregation of damaged or misfolded proteins is a protective mechanism against proteotoxic stress, abnormalities of which underlie many aging-related diseases. Here, we show that in asymmetrically dividing yeast cells, aggregation of cytosolic mis-folded proteins does not occur spontaneously but req...

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Udgivet i:Cell
Main Authors: Zhou, Chuankai, Slaughter, Brian D., Unruh, Jay R., Guo, Fengli, Yu, Zulin, Mickey, Kristen, Narkar, Akshay, Ross, Rhonda Trimble, McClain, Melainia, Li, Rong
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726438/
https://ncbi.nlm.nih.gov/pubmed/25417105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.026
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