D(2) Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways

Regulator of G-protein signaling 9-2 (RGS9-2), a member of the RGS family of Gα GTPase accelerating proteins, is expressed specifically in the striatum, which participates in antipsychotic-induced tardive dyskinesia and in levodopa-induced dyskinesia. We report that RGS9 knock-out mice develop abnor...

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Udgivet i:J Neurosci
Main Authors: Kovoor, Abraham, Seyffarth, Petra, Ebert, Jana, Barghshoon, Sami, Chen, Ching-Kang, Schwarz, Sigrid, Axelrod, Jeffrey D., Cheyette, Benjamin N. R., Simon, Melvin I., Lester, Henry A., Schwarz, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2005
Fag:
Neurobiology of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726050/
https://ncbi.nlm.nih.gov/pubmed/15728856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2840-04.2005
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