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Nuclear Translocation of the p75 Neurotrophin Receptor Cytoplasmic Domain in Response to Neurotrophin Binding

The intracellular domain of the p75 neurotrophin receptor (p75(ICD)) can be released by γ-secretase in response to the previous activation of α-secretase by phorbol esters. However, ligand-dependent release of p75(ICD) has yet to be described. We show here that nerve growth factor can induce the rel...

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Bibliographic Details
Published in:J Neurosci
Main Author: Frade, José M.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726010/
https://ncbi.nlm.nih.gov/pubmed/15703394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3798-04.2005
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