Enhanced Susceptibility to Kainate-Induced Seizures, Neuronal Apoptosis, and Death in Mice Lacking Gangliotetraose Gangliosides: Protection with LIGA 20, a Membrane-Permeant Analog of GM1

Knock-out (KO) mice lacking gangliotetraose gangliosides attributable to disruption of the gene for GM2/GD2 synthase [GalNAcT (UDP-N-acetylgalactosamine:GM3/GD3 β-1,4-N-acetylgalactosaminyltransferase; EC 2.4.1.92)] are revealing key neural functions for the complex gangliosides of brain. This study...

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Publicat a:J Neurosci
Autors principals: Wu, Gusheng, Lu, Zi-Hua, Wang, Jianfeng, Wang, Yvette, Xie, Xin, Meyenhofer, Markus F., Ledeen, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2005
Matèries:
Neurobiology of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725874/
https://ncbi.nlm.nih.gov/pubmed/16306414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3635-05.2005
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