Reversal of Maternal Programming of Stress Responses in Adult Offspring through Methyl Supplementation: Altering Epigenetic Marking Later in Life

Stress responses in the adult rat are programmed early in life by maternal care and associated with epigenomic marking of the hippocampal exon 1(7) glucocorticoid receptor (GR) promoter. To examine whether such epigenetic programming is reversible in adult life, we centrally infused the adult offspr...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Weaver, Ian C. G., Champagne, Frances A., Brown, Shelley E., Dymov, Sergiy, Sharma, Shakti, Meaney, Michael J., Szyf, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Development/Plasticity/Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725868/
https://ncbi.nlm.nih.gov/pubmed/16306417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3652-05.2005
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