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CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo
Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases are characterized by neuronal accumulation of the disease protein, suggesting that the cellular ability to handle abnormal proteins is compromised. As both a cochaperone and ubiquitin ligase, the C-terminal Hsp...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Neurosci |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Society for Neuroscience
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6725774/ https://ncbi.nlm.nih.gov/pubmed/16207874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3001-05.2005 |
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