CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo

Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases are characterized by neuronal accumulation of the disease protein, suggesting that the cellular ability to handle abnormal proteins is compromised. As both a cochaperone and ubiquitin ligase, the C-terminal Hsp...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Miller, Victor M., Nelson, Rick F., Gouvion, Cynthia M., Williams, Aislinn, Rodriguez-Lebron, Edgardo, Harper, Scott Q., Davidson, Beverly L., Rebagliati, Michael R., Paulson, Henry L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725774/
https://ncbi.nlm.nih.gov/pubmed/16207874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3001-05.2005
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