CHIP Suppresses Polyglutamine Aggregation and Toxicity In Vitro and In Vivo

Huntington's disease (HD) and other polyglutamine (polyQ) neurodegenerative diseases are characterized by neuronal accumulation of the disease protein, suggesting that the cellular ability to handle abnormal proteins is compromised. As both a cochaperone and ubiquitin ligase, the C-terminal Hsp...

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Vydáno v:J Neurosci
Hlavní autoři: Miller, Victor M., Nelson, Rick F., Gouvion, Cynthia M., Williams, Aislinn, Rodriguez-Lebron, Edgardo, Harper, Scott Q., Davidson, Beverly L., Rebagliati, Michael R., Paulson, Henry L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2005
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725774/
https://ncbi.nlm.nih.gov/pubmed/16207874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3001-05.2005
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