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Partial Mitochondrial Inhibition Causes Striatal Dopamine Release Suppression and Medium Spiny Neuron Depolarization via H(2)O(2) Elevation, Not ATP Depletion
Mitochondrial dysfunction is a potential causal factor in Parkinson's disease. We show here that acute exposure to the mitochondrial complex I inhibitor rotenone (30-100 nm; 30 min) causes concentration-dependent suppression of single-pulse evoked dopamine (DA) release monitored in real time wi...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6725568/ https://ncbi.nlm.nih.gov/pubmed/16251452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2652-05.2005 |
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