Uncoupling Protein-2 Is Critical for Nigral Dopamine Cell Survival in a Mouse Model of Parkinson's Disease

Mitochondrial uncoupling proteins dissociate ATP synthesis from oxygen consumption in mitochondria and suppress free-radical production. We show that genetic manipulation of uncoupling protein-2 (UCP2) directly affects substantia nigra dopamine cell function. Overexpression of UCP2 increases mitocho...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Andrews, Zane B., Horvath, Balazs, Barnstable, Colin J., Elseworth, John, Yang, Lichuan, Beal, M. Flynt, Roth, Robert H., Matthews, Russell T., Horvath, Tamas L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2005
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725213/
https://ncbi.nlm.nih.gov/pubmed/15634780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4269-04.2005
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