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Uncoupling protein-2 regulates lifespan in mice

The long-term effects of uncoupled mitochondrial respiration by uncoupling protein-2 (UCP2) in mammalian physiology remain controversial. Here we show that increased mitochondrial uncoupling activity of different tissues predicts longer lifespan of rats compared with mice. UCP2 reduces reactive oxyg...

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Main Authors: Andrews, Zane B., Horvath, Tamas L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2009
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2670629/
https://ncbi.nlm.nih.gov/pubmed/19141680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90903.2008
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