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Uncoupling protein-2 regulates lifespan in mice
The long-term effects of uncoupled mitochondrial respiration by uncoupling protein-2 (UCP2) in mammalian physiology remain controversial. Here we show that increased mitochondrial uncoupling activity of different tissues predicts longer lifespan of rats compared with mice. UCP2 reduces reactive oxyg...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2670629/ https://ncbi.nlm.nih.gov/pubmed/19141680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.90903.2008 |
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