Treatment with an Amyloid-β Antibody Ameliorates Plaque Load, Learning Deficits, and Hippocampal Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

PDAPP transgenic mice overexpress a mutant form of human amyloid precursor protein under control of the platelet-derived growth factor promoter in CNS neurons that causes early onset, familial Alzheimer's disease in humans. These mice, on a mixed genetic background, have been shown to have subs...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Hartman, Richard E., Izumi, Yukitoshi, Bales, Kelly R., Paul, Steven M., Wozniak, David F., Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725066/
https://ncbi.nlm.nih.gov/pubmed/15987951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0664-05.2005
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