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Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane

Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolo...

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Bibliografske podrobnosti
izdano v:J Control Release
Main Authors: Yang, Rong, Okonkwo, Obiajulu S., Zurakowski, David, Kohane, Daniel S.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724208/
https://ncbi.nlm.nih.gov/pubmed/29932959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.06.019
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