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Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane

Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolo...

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Détails bibliographiques
Publié dans:J Control Release
Auteurs principaux: Yang, Rong, Okonkwo, Obiajulu S., Zurakowski, David, Kohane, Daniel S.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724208/
https://ncbi.nlm.nih.gov/pubmed/29932959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.06.019
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