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Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane
Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolo...
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| Publié dans: | J Control Release |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6724208/ https://ncbi.nlm.nih.gov/pubmed/29932959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.06.019 |
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