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Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane
Chemical permeation enhancers (CPEs) can enable antibiotic flux across the tympanic membrane. Here we study whether combinations of CPEs (sodium dodecyl sulfate, limonene, and bupivacaine hydrochloride) are synergistic and whether they could increase the peak drug flux. Synergy is studied by isobolo...
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| Publicado no: | J Control Release |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6724208/ https://ncbi.nlm.nih.gov/pubmed/29932959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.06.019 |
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