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Assessing the Justification, Funding, Success, and Survival Outcomes of Randomized Noninferiority Trials of Cancer Drugs: A Systematic Review and Pooled Analysis

IMPORTANCE: Noninferiority trials test whether a new intervention is not worse than the comparator by a given margin. OBJECTIVES: To study the characteristics of published randomized noninferiority trials in oncology with overall survival as an end point, to assess the association of justification a...

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發表在:JAMA Netw Open
Main Authors: Gyawali, Bishal, Tessema, Frazer A., Jung, Emily H., Kesselheim, Aaron S.
格式: Artigo
語言:Inglês
出版: American Medical Association 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724156/
https://ncbi.nlm.nih.gov/pubmed/31469391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2019.9570
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